Support our Nation today - please donate here

Volunteers in Wales needed for world-first Covid-19 vaccine booster study

29 May 2021 4 minute read
A woman receives the Oxford-AstraZeneca Covid-19 vaccine at Pontcae Medical Practice on January 4, 2021 in Merthyr Tydfil, Wales.

Public Health Wales is looking for volunteers in Wales who live within a 50-mile radius of Wrexham to take part in a new clinical trial to receive a third ‘booster’ Covid-19 vaccine.

They are recruiting over 30s who have had two doses of a Covid-19 vaccine to take part in the research study, including those immunised early in the vaccination programme – for example, adults aged 75 and over or health and care workers.

The COV-Boost study is being run at Wrexham Maelor Hospital.

The trial is looking at seven different Covid-19 vaccines as potential boosters, given at least 10 to 12 weeks after a second dose as part of the ongoing vaccination programme. Volunteers could receive a different brand to the one they were originally vaccinated with.

It will be the first trial in the world to provide vital data on the impact of a third dose on patients’ immune responses. The aim will be to give scientists from around the world and the experts behind the UK’s Covid-19 vaccination programme a better idea of how effective a booster of each vaccine is in protecting people from the virus.

Dr Orod Osanlou, Consultant Physician and Principal Investigator for Public Health Wales and the COV-Boost study, said:“While the current Covid-19 vaccines are highly effective at preventing severe disease, we just don’t know how long that immune protection from vaccination will last. It’s likely additional booster vaccinations might be needed for high risk groups after a period of time and that’s why we’re doing this research.

“We want to find out how effective a third jab can be in providing protection and how effective it is to give doses from different brands, to the ones people may have originally been vaccinated with.

“Thank you to the participants in Betsi Cadwaladr University Health Board who have volunteered in vaccine trials so far. I would urge anyone who may be interested in taking part and lives close to Wrexham Maelor Hospital to register with the COV-Boost website.

“This will help us deliver this next important phase of research, and continue to keep our most vulnerable family and friends protected.”


The study is looking to include people from a wide variety of backgrounds and those from ethnic minorities are encouraged to apply.

Richard Roberts, Head of the Vaccine Preventable Disease Programme (VPDP) at Public Health Wales, said: “This vaccine study will be very helpful in developing future plans for the Covid-19 vaccination programme. Vaccine trials have been an instrumental component to the successful delivery of the Covid-19 vaccination programme so far, which has been estimated to have already saved the lives of more than 11,000 people in the UK already.

“We need further data to help us understand how long vaccine protection lasts, particularly as we move towards the autumn/winter months where we tend to see an increase in respiratory viruses. This vaccine study will also help us to understand how best to protect people now and in the future.

“All of this information will be vital to informing the future rollout of the Covid-19 vaccination programme in Wales.”

Dr Nicola Williams, Director of Support and Delivery at Health and Care Research Wales, said: “We’re so grateful to those who have already taken part in vital Covid-19 research in Wales and helped in the UK-wide effort to tackle the pandemic.

“There are still many things we don’t know about Covid-19, or our immunity to it, and that’s why it’s essential we find out those answers through research like the COV-Boost study.”

Anyone interested in finding out more and signing up can visit the study website here.

Support our Nation today

For the price of a cup of coffee a month you can help us create an independent, not-for-profit, national news service for the people of Wales, by the people of Wales.

Notify of
Inline Feedbacks
View all comments

Our Supporters

All information provided to Nation.Cymru will be handled sensitively and within the boundaries of the Data Protection Act 2018.